Translation initiation factor IF- 2 (IPR015760)

Short name: TIF_IF2

Overlapping homologous superfamilies


Family relationships


Initiation factor 2 (IF-2) is one of the three factors required for the initiation of protein biosynthesis in bacteria [PMID: 15755955]. IF-2 promotes the GTP-dependent binding of the initiator tRNA to the small subunit of the ribosome. IF-2 is a protein of about 70 to 95kDa that contains a central GTP-binding domain flanked by a highly variable N-terminal domain and a more conserved C-terminal domain. Some members of this group undergo protein self splicing that involves a post-translational excision of the intein followed by peptide ligation.

The function of IF-2 in facilitating the proper binding of initiator methionyl-tRNA to the ribosomal P site appears to be universally conserved [PMID: 10200264].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.