-
Overview
-
Structures
-
Cross-references
Ral guanine nucleotide dissociation stimulator (IPR015758)
Short name: RalGDS
Overlapping homologous superfamilies
None.
Family relationships
None.
Description
RalGDS belongs to the Ral GDP dissociation stimulator (RalGDS) family [PMID: 10760592]. It has been linked to cancer [PMID: 15766660].
RalGDS family members can act both as Ras effectors and as guanine nucleotide exchange factors (GEFs) for Ral. They act downstream of Ras and bind to the GTP-bound active form of Ras or Ras family members. They also promote the GDP to GTP exchange for Ral small GTPase, member of the Ras family [PMID: 9099691]. Due to their double action, the RalGDS proteins bridge Ras and Ral [PMID: 20478380].
GO terms
Biological Process
GO:0007264 small GTPase mediated signal transduction
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Cellular Component
No terms assigned in this category.
Contributing signatures
- PTHR23113:SF35 (PTHR23113:SF35)