Telokin/Myosin light chain kinase (IPR015725)

Short name: Telokin/Myosin_light_ch_kin

Family relationships


Smooth muscle myosin light chain kinase is a Ser/Thr protein kinase, contains 1 fibronectin type-III domain and 9 Ig-like C2-type (immunoglobulin-like) domains (based on similarity to other like proteins). These kinases phosphorylate a specific serine in the N terminus of a myosin light chain, which leads to the formation of calmodulin/MLCK signal transduction complexes, which allow selective transduction of calcium signals. In this reaction magnesium and calcium act as cofactors and the kinases are activated by phosphorylation on Tyr-478 (P11799), (Q28824). Also included in this entry is telokin, an acidic protein identical to the C-terminal portion of myosin light chain kinase [PMID: 1404391].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.