Myosin Light Chain Kinase 1, Kinase domain (IPR015725)

Short name: MLCK1_kinase_dom

Overlapping homologous superfamilies

Domain relationships


Smooth muscle myosin light chain kinase (also known as MLCK1) is a Ser/Thr protein kinase that phosphorylates phosphorylates the 20 kDa myosin regulatory light chain (RLC) of smooth and nonmuscle myosin II in the presence of Ca2+ and calmodulin, which facilitates myosin interaction with actin filaments [PMID: 16774989,PMID: 18053800].

In mice, the mylk1 gene is a large gene spanning ~250 kb and comprising at least 31 exons. It encodes at least four protein products: two isoforms of the 220 kDa MLCK (also known as endothelial, long, or nonmuscle MLCK), a 130 kDa MLCK (also known as short or smooth muscle MLCK), and telokin (also known as kinase-related protein). Transcripts encoding these products are derived from four independent promoters within the gene. Each of the promoters within the mylk1 gene exhibits cell-specific differences in their activity [PMID: 16774989]. Both 130 kDa and 220 kDa MLCK contain a kinase (catalytic) domain, while telokin does not have a kinase domain.

GO terms

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.