Talin-2 (IPR015711)

Short name: Talin-2

Family relationships



Talin is a large cytoskeletal protein that forms an antiparallel homodimer, each with an N-terminal globular head and a larger C-terminal rod. The head domain contains a FERM (4.1, ezrin, radixin, moesin) domain, which has been implicated in both integrin and actin-binding. Binding of integrin beta cytoplasmic tails to the FERM domain has been found to induce integrin activation [PMID: 12846579]. The rod domain also appears to mediate binding to both actin and integrins [PMID: 15465061]. The C-terminal rod contains an I/LWEQ domain. It has been shown that the I/LWEQ domains from mouse talin P26039 and yeast Sla2p P33338 interact with F-actin [PMID: 9159132]. The domain has four conserved blocks, the name of the domain is derived from the initial conserved amino acid of each of the four blocks [PMID: 9159132].

In vivo, talin has been shown to play a critical role in the formation of cell adhesions and regulation of integrin signalling in numerous species [PMID: 15037311]. Talin localises to some neuromuscular junction and sites of cell-cell adhesions, as well as to focal adhesions, sites of attachment to the substratum.

This entry represents talin-2.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003779 actin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.