Tob1/2 (IPR015676)

Short name: Tob1/2

Overlapping homologous superfamilies


Family relationships

  • Tob1/2 (IPR015676)


Tob1 and Tob2 are members of the BTG/Tob family.

The BTG/Tob family members contain an conserved N-terminal domain, known as APRO domain (AntiPROliferative) or BTG domain. In mammals, six family members have been identified: BTG1, BTG2/PC3/Tis21, BTG3/ANA, BTG4/PC3B, Tob1/Tob and Tob2. They interact with CAF1, a subunit of the CCR4-NOT complex. They display antiproliferative properties as their ectopic expression in a variety of cell lines reduced cell proliferation [PMID: 19746446].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.