Gastrin releasing peptide (IPR015674)
Short name: Gastrin-RP
Overlapping homologous superfamilies
- Bombesin/neuromedin-B/ranatensin peptide family (IPR000874)
- Gastrin releasing peptide (IPR015674)
Gastrin-releasing peptide (GRP) is a mammalian neuropeptide, homologue of the amphibian bombesin. It binds to the GRP receptor (GRPR, also called BB2), a member of the G-protein coupled receptor (GPCR) superfamily [PMID: 24001571]. It operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear [PMID: 12526815].
- PTHR16866:SF2 (PTHR16866:SF2)