Gastrin releasing peptide (IPR015674)

Short name: Gastrin-RP

Overlapping homologous superfamilies


Family relationships


Gastrin-releasing peptide (GRP) is a mammalian neuropeptide, homologue of the amphibian bombesin. It binds to the GRP receptor (GRPR, also called BB2), a member of the G-protein coupled receptor (GPCR) superfamily [PMID: 24001571]. It operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear [PMID: 12526815].

GO terms

Biological Process

GO:0007218 neuropeptide signaling pathway

Molecular Function

GO:0005184 neuropeptide hormone activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.