Protein phosphatase 1 regulatory subunit 1B (IPR015670)

Short name: DARPP-32

Overlapping homologous superfamilies


Family relationships


Phosphoprotein phosphatase-1 regulatory subunit 1B (PPP1R1B, also known as DARPP-32) was initially discovered as a substrate of dopamine-activated protein kinase A (PKA) in the neostriatum in the brain. It is involved in mediating the biochemical, electrophysiological, and behavioral effects controlled by dopamine and other neurotransmitters in response to drugs of abuse and psychostimulants. Dopamine activates DARPP-32 through the D1 receptor pathway and disables DARPP-32 through the D2 receptor. Glutamate, acting through the N-methyl-d-aspartate receptor, renders DARPP-32 inactive. It can be activated by phosphorylation; while phosphorylation at Thr-34 by PKA converts DARPP-32 into a potent inhibitor of protein phosphatase 1 (PP1), phosphorylation at Thr-75 transforms DARPP-32 into an inhibitor of PKA [PMID: 26872373]. A mutant form of DARPP-32 has been linked with gastric cancers [PMID: 12124342].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004864 protein phosphatase inhibitor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.