B Cell Lymphoma 9 (IPR015668)

Short name: Bcl-9/Bcl-9l

Overlapping homologous superfamilies


Family relationships



BCL9 is associated with B-cell acute lymphoblastic leukemia [PMID: 9490669]. This entry includes BCL9 and BCL9L. They are tissue-specific transcriptional cofactors that cooperate with beta-catenin. In the nucleus, Bcl9 and Bcl9l simultaneously bind beta-catenin and the transcriptional activator Pygo2 to promote the transcription of a subset of Wnt target genes. They may also have a cytoplasmic role [PMID: 28174279].

GO terms

Biological Process

GO:0060070 canonical Wnt signaling pathway

Molecular Function

GO:0008013 beta-catenin binding
GO:0003713 transcription coactivator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.