Achaete-scute transcription factor-related (IPR015660)

Short name: MASH1/Ascl1a-like

Overlapping homologous superfamilies


Family relationships



Basic helix-loop-helix proteins (bHLH) are a group of eukaryotic transcription factors that exert a determinative influence in a variety of developmental pathways. These transcription factors are characterised by a highly evolutionary conserved bHLH domain that mediates specific dimerisation [PMID: 7553065]. They facilitate the conversion of inactive monomers to trans-activating dimers at appropriate stages of development [PMID: 1755826].

Proteins in this entry include MASH1/Ascl1a and related proteins from plants, worms, insects and mammals. MASH1/Ascl1a is a regulator of axonal growth across vertebrates and can induce modifications to the intrinsic state of neurons to promote functional regeneration in response to CNS injury [PMID: 26700681, PMID: 25751153].

GO terms

Biological Process

GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.