Aminobutyraldehyde dehydrogenase (IPR015657)

Short name: Aminobutyraldehyde_DH

Overlapping homologous superfamilies

Family relationships



Aminobutyraldehyde dehydrogenase functions in the putrescine degradation pathway. It catalyses the oxidation of 4 aminobutyraldehyde to 4 aminobutyrate, a neurotransmitter. YdcW encodes gamma-aminobutyraldehyde dehydrogenase (ABALDH) in the wild-type Escherichia coli (strain K12). It is a tetramer and when coupled with YgjG putrescine transaminase in vitro, putrescine was converted into gamma-aminobutyric acid [PMID: 16023116]. The tetramer is composed of identical subunits. YdcW can also oxidize N-alkyl medium-chain aldehydes, but with a lower catalytic efficiency [PMID: 15381418]. The same enzyme from Arthrobacter sp. utilises both NAD+ and NADP+ as coenzymes. It functions optimally at pH 8.0 [PMID: 12186751].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.