Pathways & interactions
Microtubule associated protein 1A (IPR015656)
Short name: MAP1A
Overlapping homologous superfamilies
- Microtubule associated protein 1 (IPR026074)
- Microtubule associated protein 1A (IPR015656)
MAP1 is one of the first described microtubule-associated proteins (MAPs). It was discovered through its association with tubulin, and was later resolved into three distinct proteins: MAP1A, MAP1B (also called MAP5) and MAP1C. MAP1A and MAP1B are structurally related and share light chains with each other, and MAP1C was later shown to be the heavy chain of brain cytoplasmic dynein [PMID: 2470876].
MAP1A is a long, rod-shaped protein that is made up of a large heavy chain and three light chains, LC1, LC2 and LC3. Light chain binding appears to regulate the activity of MAP1A and MAP1B [PMID: 11896150]. MAP1A binds to and stabilises microtubules and can promote microtubule assembly [PMID: 7918469]. It is expressed in mature neurons and may serve a key function in synaptic plasticity [PMID: 16243028, PMID: 22252785].
- PTHR13843:SF6 (PTHR13843:SF6)