Fasciculation and elongation protein zeta 2 (IPR015641)

Short name: FEZ_2

Overlapping homologous superfamilies


Family relationships


The gene unc-76 (unc, uncoordinated) is necessary for normal axonal bundling and elongation within axon bundles in Caenorhabditis elegans. Two human homologues, fasciculation and elongation protein zeta-1 and -2 (FEZ1 and 2) have been identified [PMID: 9096408].

FEZ2 has been reported in rat, human and mouse. Similar to FEZ1, FEZ2 interactes with PKCzeta and induces neurite extension of PC12 cells when co-expressed with a constitutively active mutant of PKCzeta [PMID: 14697253].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.