Pathways & interactions
Fasciculation and elongation protein zeta 2 (IPR015641)
Short name: FEZ_2
Overlapping homologous superfamilies
- Fasciculation and elongation protein zeta, FEZ (IPR011680)
- Fasciculation and elongation protein zeta 2 (IPR015641)
The gene unc-76 (unc, uncoordinated) is necessary for normal axonal bundling and elongation within axon bundles in Caenorhabditis elegans. Two human homologues, fasciculation and elongation protein zeta-1 and -2 (FEZ1 and 2) have been identified [PMID: 9096408].
FEZ2 has been reported in rat, human and mouse. Similar to FEZ1, FEZ2 interactes with PKCzeta and induces neurite extension of PC12 cells when co-expressed with a constitutively active mutant of PKCzeta [PMID: 14697253].
- PTHR12394:SF11 (PTHR12394:SF11)