G/U mismatch-specific DNA glycosylase (IPR015637)

Short name: MUG/TDG

Overlapping homologous superfamilies

Family relationships


G:U mismatches resulting from deamination of cytosine are the most common pro-mutagenic lesions occurring in DNA. Uracil is removed in a base-excision repair pathway by uracil DNA-glycosylase (UDG), which excises uracil from both single- and double-stranded DNA.

A biochemically distinct family of DNA repair enzymes, which excises both uracil and thymine, but only from mispairs with guanine has been identified [PMID: 9489705]. Crystal structures of the mismatch-specific uracil DNA-glycosylase (MUG) from Escherichia coli, and of a DNA complex, reveal structural and functional homology to UDG despite low sequence identity [PMID: 9489705].

GO terms

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0019104 DNA N-glycosylase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.