E2F Family (IPR015633)

Short name: E2F

Overlapping homologous superfamilies


Family relationships


The E2F family of transcription factors plays a crucial role in the control of cell cycle and action of tumour suppressor proteins and is also a target of the transforming proteins of small DNA tumour viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA-binding domain, a dimerisation domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumour suppressor protein association domain which is embedded within the transactivation domain [PMID: 7739537].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.