Supervillin (IPR015628)

Short name: SV/p205

Overlapping homologous superfamilies


Family relationships


Supervillin (SV, p205) belongs to the Villin/Gelsolin family. It is a peripheral membrane protein that regulates each step of cell motility, including cell spreading [PMID: 20309963].

Supervillin interacts with many cytoskeletal proteins, such as F-actin, myosin II, the long form of myosin light chain kinase (L-MLCK), and some microtubule-dependent motors [PMID: 9382871, PMID: 22344260]. In humans it is expressed in primary macrophages and localises to a substructure of successor podosomes. It couples myosin-dependent contractility to podosomes and enables their turnover [PMID: 22344260]. It can also slow cell spreading by facilitating myosin II activation at the cell periphery [PMID: 17925381].

GO terms

Biological Process

GO:0007010 cytoskeleton organization

Molecular Function

GO:0051015 actin filament binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.