Pathways & interactions
Growth/differentiation factor 8 (IPR015616)
Short name: GDF_8
Overlapping homologous superfamilies
- Transforming growth factor-beta-related (IPR015615)
- Growth/differentiation factor 8 (IPR015616)
Transforming growth factor-beta (TGF-beta) is a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. TGF-beta-1 is a peptide of 112 amino acid residues derived by proteolytic cleavage from the C-terminal of a precursor protein.
A number of proteins are known to be related to TGF-beta-1 [PMID: 1575734, PMID: 8199356]. Proteins from the TGF-beta family are only active as homo- or heterodimer; the two chains being linked by a single disulphide bond. From X-ray studies of TGF-beta-2 [PMID: 1631557], it is known that all the other cysteines are involved in intrachain disulphide bonds. There are four disulphide bonds in the TGF-beta's and in inhibin beta chains, while the other members of this group lack the first bond.
Growth and differentiation 8 (GDF-8), or myostatin, is a member of this superfamily with a role in the control and maintenance of skeletal muscle mass. Myostatin knockout in mice increases myogenesis and decreases adipogenesis [PMID: 11855847]. Frequent sequence variation in the human myostatin (GDF8) gene as a marker for analysis of muscle-related phenotypes [PMID: 10610713].
- PTHR11848:SF150 (PTHR11848:SF150)