Tissue inhibitor of metalloprotease 4 (IPR015614)

Short name: TIMP4

Family relationships


Tissue inhibitors of metalloproteinases (TIMPs) are natural inhibitors of matrix metalloproteinases (MMPs) found in most tissues and body fluids. By inhibiting MMPs activities, they participate in tissue remodeling of the extracellular matrix (ECM). The balance between MMPs and TIMPs activities is involved in both normal and pathological events such as wound healing, tissue remodeling, angiogenesis, invasion, tumourigenesis and metastasis [PMID: 15036259].

There are four mammalian TIMPs (TIMP-1 to -4), and each TIMP has its own profile of metalloproteinase inhibition. TIMP-4 is the latest member of the TIMPs to be cloned [PMID: 8939999], and it can inhibit smooth muscle cell migration and induce apoptosis in vitro and in vivo [PMID: 15350823].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.