Family

Transcription Factor c-Jun/v-Jun (IPR015558)

Short name: C_Jun/v-Jun

Family relationships

Description

Transcription factor c-Jun (also known as transcription factor AP-1) is a member of the transcription factor activator protein (AP)-1 family, comprising Jun (c-Jun, JunB, and JunD), Fos (c-Fos, FosB, Fra1, and Fra2), ATF (ATFa, ATF-2 and ATF-3) and JDP (JDP-1 and JDP-2) family members [PMID: 15564374]. They are basic leucine zipper transcription factors that play a central role in regulating gene transcription in various biological processes [PMID: 12424143]. c-Jun was originally identified as the normal cellular counterpart of the viral Jun oncoprotein (v-Jun) encoded by an avian sarcoma virus (ASV17). The 39kDa c-Jun protein consists of a C-terminal basic region-leucine zipper (B-ZIP) DNA-binding domain and a N-terminal transcriptional activation domain.

AP-1 proteins have a alpha-helical bZIP domain, which contains a basic DNA-binding region and regularly spaced leucine residues known as the leucine zipper motif [PMID: 23787991]. They have similar protein structure and can either form homodimers or form heterodimers with other AP-1 proteins (predominantly with Jun proteins), which can then bind to TRE-like sequences (consensus sequence 5'-TGAG/CTCA-3') [PMID: 15564374]. Each of these proteins are expressed in different tissues and can be regulated in different ways, which means that every cell type has a complex mixture of AP-1 dimers with subtly different functions [PMID: 15564374].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER