Leukocyte elastase inhibitor (serpin B1) (IPR015557)

Short name: Serpin_B1

Overlapping homologous superfamilies

Family relationships

  • Serpin family (IPR000215)
    • Leukocyte elastase inhibitor (serpin B1) (IPR015557)


Leukocyte elastase inhibitor is also known as serpin B1 (MEROPS identifier I04.006). Serpins (SERine Proteinase INhibitors) belong to MEROPS inhibitor family I4 (clan ID) [PMID: 14705960].

Serpin B1 regulates the activity of neutrophil serine proteases such as elastase, cathepsin G and proteinase-3 and may play a regulatory role to limit inflammatory damage due to proteases of cellular origin [PMID: 11747453]. It also functions as a potent intracellular inhibitor of granzyme H [PMID: 23269243]. In mouse, four different homologues of human serpin B1 have been described [PMID: 12189154].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004867 serine-type endopeptidase inhibitor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.