Plasminogen activator inhibitor-2 (IPR015556)

Short name: PAI-2

Overlapping homologous superfamilies


Family relationships

  • Serpin family (IPR000215)
    • Plasminogen activator inhibitor-2 (IPR015556)


Plasminogen activator inhibitor 2 (PAI-2; MEROPS identifier I04.007) is a serpin (SERine Proteinase INhibitor). Serpins belong to MEROPS inhibitor family I4 (clan ID) [PMID: 14705960].

PAI-2 has antiapoptosis activity, probably related to its interaction with the proteasome subunit PSMbeta1 [PMID: 14732874]. PAI-2 might be an important factor in regulating cell death in TNF-mediated inflammatory processes [PMID: 7499264]. Its crystal structure has been reported [PMID: 10368272].

GO terms

Biological Process

GO:0043066 negative regulation of apoptotic process

Molecular Function

GO:0004867 serine-type endopeptidase inhibitor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.