Glucagon (IPR015550)

Short name: Glucagon

Overlapping homologous superfamilies


Family relationships



A number of polypeptidic hormones, mainly expressed in the intestine or the pancreas, belong to a group of structurally related peptides [PMID: 3133967, PMID: 3291691]. Once such hormone, glucagon is widely distributed and produced in the alpha-cells of pancreatic islets [PMID: 4076759]. It affects glucose metabolism in the liver [PMID: 6577439] by inhibiting glycogen synthesis, stimulating glycogenolysis and enhancing gluconeogenesis. It also increases mobilisation of glucose, free fatty acids and ketone bodies, which are metabolites produced in excess in diabetes mellitus. Glucagon is produced, like other peptide hormones, as part of a larger precursor (preproglucagon), which is cleaved to produce glucagon, glucagon-like protein I and glucagon-like protein II [PMID: 3260236]. The structure of glucagon itself is fully conserved in all known mammalian species [PMID: 4076759].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005179 hormone activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.