Interleukin-12 beta (IPR015528)

Short name: IL-12_beta

Overlapping homologous superfamilies

Family relationships



Interleukins are a group of cytokines that have important roles in cell growth, differentiation, and motility, and in the functioning of the immune system.

Interleukin-12 (also known as natural killer cell stimulatory factor, and cytotoxic lymphocyte maturation factor) is a 75 kDa heterodimer composed of two genetically unrelated subunits - an alpha chain (p35 subunit) and a beta chain (p40 subunit). Production of the cytokine plays an important role in the generation of cell-mediated immunity against many infectious pathogens [PMID: 10426995]. The interluekin-12 beta chain also associates with interleukin-23 alpha to form interleukin-23 [PMID: 11114383], a proinflammatory cytokine that is overexpressed in and around tumour tissues, where it induces local inflammation and promotes tumour development [PMID: 18490716].

This entry represents Interleukin-12 beta.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.