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Overview
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Pathways & interactions
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Cross-references
Imaginal disc growth factor (IPR015520)
Short name: IDGF
Overlapping homologous superfamilies
- Glycoside hydrolase superfamily (IPR017853)
Family relationships
None.
Description
Imaginal disc growth factors (IDGFs), also known as chitinase-like proteins, are soluble factors involved in the regulation of proliferation in imaginal discs [PMID: 11444043]. They are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster [PMID: 12242232]. The IDGFs have an eight-stranded alpha/beta barrel fold and are related to the glycosyl hydrolase family 18 (GH18) chitinases, but they have an amino acid substitution known to abolish chitinase catalytic activity [PMID: 17594485]. IDGFs may have evolved from chitinases to gain new functions as growth factors, interacting with cell surface glycoproteins involved in growth-promoting processes [PMID: 11821393].
Contributing signatures
- PTHR11177:SF235 (PTHR11177:SF235)
- cd02873 (GH18_IDGF)