Family

Deoxycytidylate deaminase-related (IPR015517)

Short name: dCMP_deaminase-rel

Family relationships

Description

Deoxycytidylate deaminase (EC:3.5.4.12) (dCMP deaminase) hydrolyzes deoxycytidylate mono phosphate (dCMP) into deoxyuridine mono phosphate (dUMP), thus providing the nucleotide substrate for thymidylate synthase. The enzyme requires zinc for catalytic activity which is regulated by the ratio of dCTP to dTTP, both the end products of the pyrimidine salvage pathway [PMID: 7685356, PMID: 8428902, PMID: 18255096].

This entry also includes CDADC1 (cytidine and dCMP deaminase domain-containing protein 1), also known as testis development protein NYD-SP15, which may play an important role in testicular development and spermatogenesis [PMID: 16955368].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
  • cd01286 (deoxycytidylate_deaminase)
PANTHER