Semaphorin 4F (IPR015512)

Short name: Semaphorin_4F

Overlapping homologous superfamilies

Family relationships

  • Semaphorin (IPR027231)
    • Semaphorin 4F (IPR015512)


Semaphorins were first cloned as recognised mediators of cellular guidance, and consist of a large family of phylogenetically conserved secreted and transmembrane signalling proteins. Among the best-characterised vertebrate Semaphorins are the five secreted Class 3 members that contain an approximately 500 amino acid N-terminal Semaphorin domain, a C2 type immunoglobulin domain, and a highly basic C-terminal tail [PMID: 11956234]. Two receptor families have been implicated in mediating the actions of class 3 semaphorins: the Neuropilins and Plexins. The nine known vertebrate Plexins are divided into four subfamilies (A through D) based on structure [PMID: 10520995]. Several Plexins have been shown to interact directly with some class 4, 7 and V Semaphorins, but class 3 Semaphorins, however, do not appear to bind Plexins directly. Rather, the functional receptors for these Semaphorins are complexes of Neuropilins and A-type Plexins, with the former serving as the ligand-binding moiety and the latter the signal-transducing component [PMID: 10520995, PMID: 10520994]. There are two Neuropilins (NP-1 and NP-2) that bind the five class 3 Semaphorins preferentially. In particular, Sema3A binds NP-1, whereas Sema3F utilises NP-2, while NP-1 and NP-2 heterodimers are thought to serve as functional receptors for Sema3C [PMID: 10934324].

Semaphorin 4F may be involved in the injury response of intramedullary axotomized motoneurons [PMID: 15094469].

GO terms

Biological Process

GO:0007411 axon guidance

Molecular Function

GO:0030215 semaphorin receptor binding

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.