Ribosomal RNA large subunit methyltransferase E (IPR015507)

Short name: rRNA-MeTfrase_E

Overlapping homologous superfamilies

Family relationships


The ribosomal RNA large subunit methyltransferase E (EC:2.1.1) methylates the 23S rRNA. It specifically methylates the uridine in position 2552 of 23s rRNA in the 50S particle using S-adenosyl-L-methionine as a substrate [PMID: 10748051]. It was previously known as cell division protein FtsJ.

This entry represents the ribosomal RNA large subunit methyltransferase E family, which also includes tRNA (uridine-2'-O-)-methyltransferases. This enzyme methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop [PMID: 11927565].

GO terms

Biological Process

GO:0001510 RNA methylation

Molecular Function

GO:0008168 methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.