Family

Caveolin-1 (IPR015504)

Short name: Caveolin_1

Family relationships

  • Caveolin (IPR001612)
    • Caveolin-1 (IPR015504)

Description

Caveolins [PMID: 8567687, PMID: 8552590] are a family of integral membrane proteins that are the principal components of caveolae membranes. Cavoleae are flask-shaped plasma membrane invaginations whose exact cellular function is not yet clear. Caveolins may act as scaffolding proteins within caveolar membranes. They interact directly with G-protein alpha subunits and can functionally regulate their activity.

Currently, three different forms of caveolins are known: caveolin-1 (or VIP21), caveolin-2 and caveolin-3 (or M-caveolin).

Caveolins are proteins of about 20 kDa, they form high molecular mass homo-oligomers. Structurally they seem to have N-terminal and C-terminal hydrophilic segments and a long central transmembrane domain that probably forms a hairpin in the membrane. Both extremities are known to face the cytoplasm.

Caveolin-1 (VIP21) was first identified as a tyrosine-phosphorylated protein in Rous sarcoma virus transformed cells that was enriched in both caveolae and vesicles targeted to the apical surface of polarized epithelial cells. Caveolin-1 has a function in intracellular and extracellular lipid transport [PMID: 12189159].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER