Cortactin (IPR015503)

Short name: Cortactin

Overlapping homologous superfamilies


Family relationships



Cortactin is a key regulator of actin polymerisation in response to tyrosine kinase signalling [PMID: 22297987]. It was first identified as a tyrosine-phosphorylated protein in v-Src infected fibroblasts [PMID: 2110361]. It contains several domains: an N-terminal acidic (NTA) domain, a central repeat region and a C-terminal Src homology 3 (SH3) domain. The central repeat region binds to actin filaments, the NTA domain binds to the Arp2/3 complex and the SH3 domain interacts with N-WASp, Arg and WIP [PMID: 22297987]. When activated, cortactin can recruit Arp2/3 complex to existing actin filaments to nucleate a new actin filament.

Cortactin is involved in the regulation of cell migration, lamellipodia formation, invadopodia formation and endocytosis [PMID: 17403031]. Cortactin can be phosphorylated by Src at several sites, and also binds directly to the SH2 domain of SRC. The non-receptor kinases, such as Fyn, Syk and Fer may also play a role in cortactin tyrosine phosphorylation. The structure of cortactin has been solved [PMID: 22297987].

GO terms

Biological Process

GO:0030041 actin filament polymerization

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.