Glypican-1 (IPR015502)

Short name: Glypican-1

Overlapping homologous superfamilies


Family relationships

  • Glypican (IPR001863)
    • Glypican-1 (IPR015502)


Glypicans [PMID: 8589707, PMID: 7657705] are a group of heparan sulphate proteoglycans which are anchored to cell membranes by a glycosylphosphatidylinositol (GPI) linkage. Structurally, these proteins consist of three separate domains:

  • a) A signal sequence;
  • b) An extracellular domain of about 500 residues that contains 12 conserved cysteines which is probably involved in disulphide bonds and also contains the sites of attachment of the heparan sulphate glycosaminoglycan side chains;
  • c) A C-terminal hydrophobic region is post-translationally removed after formation of the GPI-anchor.

Six members (GPC1-6) are known in vertebrates [PMID: 11474185]. A role for GPC1 in pancreatic cancer progression has also been proposed [PMID: 11320054].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.