T-cell surface glycoprotein CD3 delta chain (IPR015485)

Short name: CD3D

Overlapping homologous superfamilies

Family relationships


The closely related CD3 gamma and delta subunits constitute part of the invariant portion of the T cell receptor (TCR) complex. Both are transmembrane proteins with immunoglobulin-like domains in their extracellular regions. Each protein contains a single immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain that becomes phosphorylated upon ligation of the invariant TCR chains and provides binding sites for various downstream effectors [PMID: 14552840].

GO terms

Biological Process

GO:0007166 cell surface receptor signaling pathway

Molecular Function

GO:0004888 transmembrane signaling receptor activity

Cellular Component

GO:0042101 T cell receptor complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.