Family

CD3 protein, epsilon/gamma/delta subunit (IPR015484)

Short name: CD3_esu/gsu/dsu

Family relationships

Description

The closely related CD3 epsilon, gamma and delta subunits constitute part of the invariant portion of the T cell receptor (TCR) complex. Both are transmembrane proteins with immunoglobulin-like domains in their extracellular regions. Each protein contains a single immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain that becomes phosphorylated upon ligation of the invariant TCR chains and provides binding sites for various downstream effectors [PMID: 14552840].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER