Pancreatic hormone (IPR015480)

Short name: Pancreatic_hormone

Overlapping homologous superfamilies


Family relationships


Pancreatic hormone (PP) [PMID: 6107857] is a peptide synthesized in pancreatic islets of Langherhans, which acts as a regulator of pancreatic and gastrointestinal functions.

The hormone is produced as a larger propeptide, which is enzymatically cleaved to yield the mature active peptide: this is 36 amino acids in length [PMID: 3031687] and has an amidated C terminus [PMID: 2599092]. The hormone has a globular structure, residues 2-8 forming a left-handed poly-proline-II-like helix, residues 9-13 a beta turn, and 14-32 an alpha-helix, held close to the first helix by hydrophobic interactions [PMID: 3031687]. Unlike glucagon, another peptide hormone, the structure of pancreatic peptide is preserved in aqueous solution [PMID: 2067973]. Both N and C termini are required for activity: receptor binding and activation functions may reside in the N and C termini respectively [PMID: 3031687].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.