Cyclin A2, chordates (IPR015453)

Short name: Cyclin_A2_chordates

Family relationships



Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [PMID: 12910258], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.

Several types of cyclins have been identified, with the mammalian A-type cyclin family consisting of two members: cyclin A1 and A2. A-type cyclins are involved at both G1/S and G2/M transitions of the cell cycle. Cyclin A2 activates cdc2 (Cdk1) on passage into mitosis and Cdk2 at the G1/S transition [PMID: 8988174]. It is involved in cytoskeletal dynamics, epithelial-mesenchymal transition (EMT) and metastasis [PMID: 25993989].

GO terms

Biological Process

GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity

Molecular Function

GO:0019901 protein kinase binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.