Pathways & interactions
TATA-Box binding protein-like (IPR015445)
Short name: TBP-like
Overlapping homologous superfamilies
- TATA-box binding protein (IPR000814)
- TATA-Box binding protein-like (IPR015445)
TATA-Box binding protein (TBP) is a general factor that plays a central role in the activation of eukaryotic genes transcribed by RNA polymerase II [PMID: 2374612, PMID: 2197561]. TBP binds specifically to the TATA-box promoter element, which lies close to the position of transcription initiation.
TBP-like factors (TLF; also called TLP, TRF, TRP) are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the basal transcription machinery. Yet, in contrast to TBPs, TLFs seem not to interact with the TATA-box and even have a negative effect on the transcription of TATA-containing promoters. Recent results indicate that TLFs are involved in the transcription via TATA-less promoters [PMID: 11051541, PMID: 10470030, PMID: 12878007, PMID: 15767669, PMID: 16858867, PMID: 14685269].
This entry refers to TATA box-binding protein-like proteins.
- cd04517 (TLF)