Aldose 1-epimerase (IPR015443)

Short name: Aldose_1-epimerase

Overlapping homologous superfamilies

Family relationships


Aldose 1-epimerase (EC: (mutarotase) is the enzyme responsible for the anomeric interconversion of D-glucose and other aldoses between their alpha- and beta-forms. The sequence of mutarotase from two bacteria, Acinetobacter calcoaceticus and Streptococcus thermophilus is available [PMID: 1694527]. It has also been shown that, on the basis of extensive sequence similarities, a mutarotase domain seems to be present in the C-terminal half of the fungal GAL10 protein that encodes, in the N-terminal part, UDP-glucose 4-epimerase. The best conserved region in the sequence of mutarotase is cantered around a conserved histidine residue which may be involved in the catalytic mechanism.

GO terms

Biological Process

GO:0019318 hexose metabolic process

Molecular Function

GO:0016853 isomerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.