Cyclin L1 (IPR015431)

Short name: Cyclin_L1

Overlapping homologous superfamilies


Family relationships



Cyclin L is a transcriptional regulator involved in the regulation of RNA polymerase II transcription and participating in regulating the pre-mRNA splicing process. Cyclin L1 and cyclin L2 are two closely related members of the cyclin family that contain an arginine-serine dipeptide repeat within the C-terminal domain, which is the hallmark of the SR family of splicing factors and probably plays a role in protein-protein interactions [PMID: 11980906, PMID: 17494991].

Cyclins interact with and activate cyclin-dependent kinase (CDK)1 subunits, playing important roles in the regulation of cell cycle progression. Cyclins can be classified into two major groups: the cell cycle regulator cyclins, composed primarily of cyclin A, B, D1, D2, D3, E, and F, function with their CDK partners including CDK1, -2, -3, and -4 to regulate promotion of the cell cycle; the transcription regulator cyclins, which include cyclin C, H, K, L1, T1, and T2, work together with CDK7, -8, and -9 and tend to play roles in transcriptional regulation [PMID: 14684736].

GO terms

Biological Process

GO:0006396 RNA processing
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.