Family

Cyclin L1 (IPR015431)

Short name: Cyclin_L1

Family relationships

None.

Description

Cyclin L is a transcriptional regulator involved in the regulation of RNA polymerase II transcription and participating in regulating the pre-mRNA splicing process. Cyclin L1 and cyclin L2 are two closely related members of the cyclin family that contain an arginine-serine dipeptide repeat within the C-terminal domain, which is the hallmark of the SR family of splicing factors and probably plays a role in protein-protein interactions [PMID: 11980906, PMID: 17494991].

Cyclins interact with and activate cyclin-dependent kinase (CDK)1 subunits, playing important roles in the regulation of cell cycle progression. Cyclins can be classified into two major groups: the cell cycle regulator cyclins, composed primarily of cyclin A, B, D1, D2, D3, E, and F, function with their CDK partners including CDK1, -2, -3, and -4 to regulate promotion of the cell cycle; the transcription regulator cyclins, which include cyclin C, H, K, L1, T1, and T2, work together with CDK7, -8, and -9 and tend to play roles in transcriptional regulation [PMID: 14684736].

GO terms

Biological Process

GO:0006396 RNA processing
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER