Family

Synaptotagmin 7 (IPR015427)

Short name: Synaptotagmin7

Family relationships

None.

Description

Synaptotagmins are synaptic vesicle membrane proteins found in abundance in nerve cells and some endocrine cells [PMID: 7697723, PMID: 7961887]. The amino acid sequence of synaptotagmin comprises a single transmembrane region with a short vesicular N-terminal region, and a cytoplasmic C-terminal region containing 2 internal repeats similar to the C2 regulatory domain of protein kinase C. The protein is believed to be important in the docking and fusion of synaptic vesicles with the plasma membrane, i.e. with neurotransmitter release [PMID: 7697723, PMID: 7961887].

Synaptotagmin 7 is a member in the synaptotagmin family, and is expressed in both brain and non-neural tissues, such as heart and lung [PMID: 7791877]. It has been shown that its expression was significantly associated with the expressions of the known prostate cancer-associated genes, such as PSA, PAP, etc, suggesting that the expression of Syt7 is associated with prostate cancer [PMID: 10613842].

GO terms

Biological Process

GO:0006887 exocytosis

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER