Family

Synaptotagmin 7 (IPR015427)

Short name: Synaptotagmin7

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Synaptotagmins are synaptic vesicle membrane proteins found in abundance in nerve cells and some endocrine cells [PMID: 7697723, PMID: 7961887]. The amino acid sequence of synaptotagmin comprises a single transmembrane region with a short vesicular N-terminal region, and a cytoplasmic C-terminal region containing 2 internal repeats similar to the C2 regulatory domain of protein kinase C. The protein is believed to be important in the docking and fusion of synaptic vesicles with the plasma membrane, i.e. with neurotransmitter release [PMID: 7697723, PMID: 7961887].

Synaptotagmin 7, a member of class 2 synaptotagmins, is located in presynaptic plasma membranes in neurons, dense-core vesicles in endocrine cells, and lysosomes in fibroblasts. It has been shown to play a role in regulation of Ca2+-dependent lysosomal exocytosis in fibroblasts and also functions as a vesicular Ca2+-sensor [PMID: 10725327, PMID: 24569478]. It is distinguished from the other synaptotagmins by having over 12 splice forms [PMID: 11739399].

GO terms

Biological Process

GO:0006887 exocytosis

Molecular Function

GO:0005544 calcium-dependent phospholipid binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER