Domain

Autophagy-related, C-terminal (IPR015412)

Short name: Autophagy-rel_C

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

Eukaryotes have developed an evolutionarily conserved process, termed autophagy, to survive starvation conditions. The vacuole or lysosome mediates the turnover and recycling of non-essential intracellular material for re-use in critical biosynthetic reactions. ATG2 (also known as Apg2) is required for the formation and/or completion of cytosolic sequestering vesicles that are needed for vacuolar import through both the Cvt pathway and autophagy, as well as for the specific degradation of peroxisomes. Apg2 is a peripheral membrane protein that localises to the previously identified perivacuolar compartment that contains Apg9 [PMID: 11382760].

This entry represents the C-terminal domain of Apg2 and related proteins.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam