XLF family (IPR015381)

Short name: XLF_fam

Overlapping homologous superfamilies


Family relationships



XLF (also called Cernunnos) is involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. XLF and XRCC4 form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair [PMID: 23442139]. It directly interacts with the XRCC4-Ligase IV complex and siRNA-mediated downregulation of XLF in human cell lines leads to radio-sensitivity and impaired DNA non-homologous end-joining [PMID: 16439205]. XLF is homologous to the yeast non-homologous end-joining factor Nej1 [PMID: 16571728]. This family contains Nej1 (non-homologous end-joining factor) and Lif1.

GO terms

Biological Process

GO:0006302 double-strand break repair

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.