XLF/Cernunnos (IPR015381)

Short name: XLF/Cernunnos

Family relationships



XLF (also called Cernunnos) interacts with the XRCC4-DNA ligase IV complex to promote DNA non-homologous end-joining. It directly interacts with the XRCC4-Ligase IV complex and siRNA-mediated downregulation of XLF in human cell lines leads to radio-sensitivity and impaired DNA non-homologous end-joining [PMID: 16439205]. XLF is homologous to the yeast non-homologous end-joining factor Nej1 [PMID: 16571728].

GO terms

Biological Process

GO:0006281 DNA repair

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.