Domain

WIBG, Mago-binding (IPR015362)

Short name: WIBG_mago-bd

Domain relationships

None.

Description

Partner of Y14 and mago (PYM, also known as WIBG) is a key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation [PMID: 18026120, PMID: 19410547].

The N-terminal domain of PYM adopts a small globular all-beta-domain structure, with a three-stranded beta-sheet and a contiguous beta-hairpin. It binds to both Mago and Y14 [PMID: 14968132].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam