Immunomodulatory protein FIP-Fve, fungal (IPR015339)

Short name: Immunomodulatory_FIP-Fve_fun

Overlapping homologous superfamilies

Family relationships



FIP-Fve (Fungal Immunomodulatory Protein Fve) is a major fruiting body protein from Flammulina velutipes, a mushroom possessing immunomodulatory activity [PMID: 7705335]. It stimulates lymphocyte mitogenesis, suppresses systemic anaphylaxis reactions and oedema, enhances transcription of IL-2, IFN-gamma and TNF-alpha, and haemagglutinates red blood cells. It appears to be a lectin with specificity for complex cell-surface carbohydrates. Fve adopts a tertiary structure consisting of an immunoglobulin-like beta-sandwich, with seven strands arranged in two beta sheets, in a Greek-key topology. It forms a non-covalently linked homodimer containing no Cys, His or Met residues; dimerisation occurs by 3-D domain swapping of the N-terminal helices and is stabilised predominantly by hydrophobic interactions [PMID: 12948495].

GO terms

Biological Process

GO:0002682 regulation of immune system process

Molecular Function

GO:0030246 carbohydrate binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
  • PD030553 (Immunomodulatory_FIP-Fve_fun)