Domain

Exostosin , C-terminal (IPR015338)

Short name: EXT_C

Domain relationships

Description

This entry represents the C-terminal domain of exostosins (EXTs), which belong to the glycosyltransferase 47 family. In humans, there are five exostosins identified, including EXT1-2, EXTL1-3. They are glycosyltransferases required for the biosynthesis of heparan-sulfate [PMID: 11518722]. They may be tumour suppressors in humans [PMID: 11518722].

EXTL2 catalyses the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analogue of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate [PMID: 12562774].

This domain is also found in Arabidopsis glycosyltransferase 64 family members [PMID: 16045474].

GO terms

Biological Process

GO:0006024 glycosaminoglycan biosynthetic process
GO:0015012 heparan sulfate proteoglycan biosynthetic process

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam