Ste50, sterile alpha motif (IPR015316)

Short name: SAM_Ste50

Overlapping homologous superfamilies

Domain relationships



Ste50-like proteins have a SAM domain at the N terminus and Ras-associated UBQ superfamily domain at the C terminus. They participate in regulation of mating pheromone response, invasive growth and high osmolarity growth response, and contribute to cell wall integrity in vegetative cells. Ste50 of S.cerevisiae acts as an adaptor protein between G protein and MAP triple kinase Ste11. Ste50 proteins are able to form homo-oligomers, binding each other via their SAM domains, as well as heterodimers and heterogeneous complexes with SAM domain or SAM homodimers of MAPKKK Ste11 protein kinase [PMID: 14573615, PMID: 18431466, PMID: 16337230, PMID: 16428446, PMID: 15327964, PMID: 15544813, PMID: 16543225, PMID: 1494345, PMID: 12764668].

The fungal Ste50 SAM domain consists of five helices, which form a compact, globular fold. It is required for mediation of homodimerisation and heterodimerisation (and in some cases oligomerisation) of the protein [PMID: 14573615].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.