Porin family, mycobacterial-type (IPR015286)

Short name: Porin_fam_mycobact-type

Overlapping homologous superfamilies

Family relationships



MspA is a membrane porin produced by Mycobacteria, allowing hydrophilic nutrients to enter the bacterium. The protein forms a tightly interconnected octamer with eightfold rotation symmetry that resembles a goblet and contains a central channel. Each subunit fold contains a beta-sandwich of Ig-like topology and a beta-ribbon arm that forms an oligomeric transmembrane barrel [PMID: 14976314]. The Mycobacterium smegmatis genome encodes four paralogues, MspA, MspB, MspC and MspD, which are also represented by this entry.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.