Signal recognition particle (SRP) receptor alpha subunit, N-terminal (IPR015284)

Short name: SRX_dom

Overlapping homologous superfamilies

Domain relationships



This domain (SRX domain) is found in the signal recognition particle receptor (SR) subunit alpha, also known as Srp101 in budding yeast, which consist of a central six-stranded anti-parallel beta-sheet sandwiched by helix alpha1 on one side and helices alpha2-alpha4 on the other. The SRX domain of SRalpha can bind SRbeta, and the affinity of GDP bound SRbeta for SRX is several orders of magnitude lower compared to the GTP bound state [PMID: 12654246].

Srp101 is a homologue of the human SRalpha (signal recognition particle receptor alpha subunit), which is part of the SR complex involved in targeting the nascent secretory proteins to the endoplasmic reticulum membrane system. Similar to human SRslpha, Srp101 also forms SR complex with the SRbeta subunit, Srp102 [PMID: 9679135].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005515 protein binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.