Uncharacterised domain UPF0029, Impact, C-terminal (IPR015269)

Short name: UPF0029_Impact_C

Overlapping homologous superfamilies

Domain relationships



Members of this entry are a set of functionally uncharacterised hypothetical bacterial proteins. They adopt a ferredoxin-like fold, with a beta-alpha-beta-beta-alpha-beta arrangement [PMID: 15103642].

This entry contains the protein Impact, which is a translational regulator that ensures constant high levels of translation under amino acid starvation. It acts by interacting with Gcn1/Gcn1L1, thereby preventing activation of Gcn2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. It is evolutionary conserved from eukaryotes to archaea [PMID: 11116084].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.