Family

Repressor of RNA polymerase III transcription Maf1 (IPR015257)

Short name: Maf1

Family relationships

None.

Description

Maf1 is a negative regulator of RNA polymerase III [PMID: 11438659, PMID: 16762835]. It inhibits the de novo assembly of TFIIIB onto DNA [PMID: 17785443]. Maf1 represses Pol III in response to DNA damage, oxidative stress, growth to stationary phase, treatment with rapamycin or chlorpromazine, and blocking of the secretory pathway [PMID: 15196897]. It targets the initiation factor TFIIIB [PMID: 12504022]. Its structure has been solved [PMID: 20887893].

GO terms

Biological Process

GO:0016480 negative regulation of transcription from RNA polymerase III promoter

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF
PANTHER
Pfam