Domain

Talin, central (IPR015224)

Short name: Talin_cent

Domain relationships

None.

Description

This domain adopts a structure consisting of five alpha helices that fold into a bundle. It contains a vinculin binding site (VBS) composed of a hydrophobic surface spanning five turns of helix four. Activation of the VBS causes subsequent recruitment of vinculin, which enables maturation of small integrin/talin complexes into more stable adhesions. Formation of the complex between VBS and vinculin requires prior unfolding of this middle domain: once released from the talin hydrophobic core, the VBS helix is then available to induce the 'bundle conversion' conformational change within the vinculin head domain thereby displacing the intramolecular interaction with the vinculin tail, allowing vinculin to bind actin [PMID: 15272303].

GO terms

Biological Process

GO:0007016 cytoskeletal anchoring at plasma membrane

Molecular Function

GO:0005200 structural constituent of cytoskeleton

Cellular Component

GO:0005925 focal adhesion
GO:0001726 ruffle

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam