Domain

Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal (IPR015211)

Short name: Peptidase_M1_C

Domain relationships

  • Armadillo-type fold (IPR016024)
    • Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal (IPR015211)

Description

This C-terminal domain is found in peptidases belonging to MEROPS peptidase family M1, particularly: aminopeptidase-1 of Caenorhabditis elegans, aminopeptidase O, aminopeptidase B and the bifunctional leukotriene A4 hydrolase/aminopeptidase.

The domain adopts a structure consisting of two layers of parallel alpha-helices, five in the inner layer and four in the outer, arranged in an antiparallel manner, with perpendicular loops containing short helical segments on top. It is required for the formation of a deep cleft harbouring the catalytic Zn2+ site in leukotriene A4 hydrolase [PMID: 11175901].

GO terms

Biological Process

GO:0019370 leukotriene biosynthetic process

Molecular Function

GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam