Domain

Tower (IPR015205)

Short name: Tower

Domain relationships

None.

Description

This domain adopts a secondary structure consisting of a pair of long, antiparallel alpha-helices (the stem) that support a three-helix bundle (3HB) at their end. The 3HB contains a helix-turn-helix motif and is similar to the DNA binding domains of the bacterial site-specific recombinases, and of eukaryotic Myb and homeodomain transcription factors. The Tower domain has an important role in the tumour suppressor function of BRCA2, and is essential for appropriate binding of BRCA2 to DNA [PMID: 12228710].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam